The frequencies of the various BM cell types differ by several orders of magnitude11, imposing a challenge to scRNAseq approaches. To capture both highly abundant and extremely rare BM-resident cells, we performed droplet-based scRNAseq12 of cells from total mouse BM, followed by progressive depletion of the … See more To confirm the spatial relationships of BM cell types identified by LCM-seq, we determined marker combinations specific to the individual … See more Key biological processes occurring in the BM are thought to be mediated by the coordinated action of a diverse set of cytokines and growth … See more We applied RNA-Magnet to soluble signalling mediators (for example cytokines, growth factors and so on) and their receptors to … See more WebThe quiescent pre-adipocyte-like subset of CXCL12+stromal cells (“Adipo-CAR” cells) is localized to sinusoidal surfaces and particularly enriched for hematopoiesis-supporting cytokines. However, detailed characteristics of these CXCL12+pre- adipocyte-like stromal cells and how they contribute to marrow adipogenesis remain largely unknown.
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WebJul 12, 2024 · Top five markers predicted by sc2marker in Adipo-CAR and Osteo-CAR cells: Ridge plots of top five markers identified in the mouse bone marrow data set in … WebMar 21, 2024 · ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) is a Protein Coding gene. Diseases associated with ADIPOQ include Adiponectin, Serum Level Of, Quantitative Trait Locus 1 and Fatty Liver Disease.Among its related pathways are AMP-activated protein kinase signaling and Integration of energy metabolism.Gene Ontology … gay officers action league new york
A bone-specific adipogenesis pathway in fat-free mice defines key ...
WebJul 12, 2024 · Top five markers predicted by sc2marker in Adipo-CAR and Osteo-CAR cells: Ridge plots of top five markers identified in the mouse bone marrow data set in Adipo … WebWe have suggested that CAR cells are adipo-osteogenic progenitors, which produce large amounts of hematopoietic cytokines, CXCL12 and SCF, before they differentiate into … WebJul 1, 2024 · Interestingly, the two newly defined Adipo-and Osteo-CAR cells differ significantly across distinct peri-vascular micro-niches, and serve as not only primary sources of signals interacting to... gay of heroes