WebCD55, also known as DAF (decay accelerating factor), is expressed on the surfaces of red blood cells, hematopoietic cells and many non-hemotopietic cells. There are two isoforms of mouse CD55, a GPI-anchored isofrom and a transmembrane isoform. Both are recognized by RIKO-3. The function of CD55 is to protect damage by complement deposition. WebA novel CD55 chimeric monoclonal antibody was developed that may boost the immune response, thereby suppressing cancer. The CD55 antibody treatment activated complement and therefore suppressed the proliferation, invasion and migration of colorectal cancer cells. This tumoricidal activity is partly explained by the inflammatory response via the ...
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WebFeb 1, 2008 · Evidence is conflicting related to the role CMC plays in mediating the antitumor effects of rituximab. Van Meerten et al used target cells that express varying amounts of CD20 on their surface, and concluded that rituximab-mediated CMC depends on CD20 expression level and acts in a complementary manner to ADCC. 2 Target cell expression … WebJan 18, 2024 · Background: CD55 plays an important role in the development of colon cancer. This study aims to evaluate the expression of CD55 in colon cancer and discover how it is regulated by transcriptional factors and miRNA.. Methods: The expression of CD55 was explored by TIMER2.0, UALCAN, and Human Protein Atlas (HPA) databases. … cnbc - englewood cliffs
Silencing of CD59 enhanced the sensitivity of HT29 cells to 5 ... - PubMed
WebThis gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in … WebJun 28, 2024 · CD55 can convey a costimulatory signal for T-cell activation and the production of interleukin-10, a cytokine that is inhibitory to intestinal inflammation. 24,25 … WebApr 20, 2004 · Abstract. Purpose: CD55 is a complement regulatory protein expressed by cells to protect them from bystander attack by complement. CD55 is overexpressed on some tumor cell lines, and in colorectal carcinomas, it has been shown to be an indicator of poor prognostic.Experimental Design: A large set of samples (480) from patients with primary … cnbc english india