Cisplatin excretion
Web1152 rows · Jun 13, 2005 · Cisplatin may decrease the excretion rate of … Webof cisplatin with urine from healthy subjects, except that the proportions are different. The parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the dose excreted within one hour after administration of 50 mg/m2. The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and
Cisplatin excretion
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WebSep 18, 2024 · Theoretically, cisplatin may not be as useful for slow-growing tumors. The drug is primarily excreted in the urine, with 10% in the bile. Its initial half-life is approximately 20 to 30 minutes, with a terminal … WebIn comparison with cisplatin, carboplatin has longer half-lives of ultrafilterable platinum (23 and 120 min versus 6 and 36 min for distribution and initial elimination half-lives, respectively) and a higher cumulative urinary platinum excretion (77 versus 28% of the dose in 24 h), both due to the lower protein binding of carboplatin.
WebJul 22, 2009 · At 24 hours after cisplatin administration, a cumulative urinary excretion amounting to 45% of the administered dose was observed in Oct1/2 (−/−) mice compared to 91% in wildtype animals ( P = 0.0008), and only 56% of the dose was recovered in Oct1/2 (−/−) mice ( P = 0.0016) ( Figure 2A) within the sample collection period. WebCisplatin is an antineoplastic agent that is FDA approved for the treatment of metastatic testicular tumors, metastatic ovarian tumors, and advanced bladder cancer. There is a Black Box Warning for this drug as shown here. Common adverse reactions include anemia, leukopenia, and thrombocytopenia . Adult Indications and Dosage
WebOct 4, 2024 · Most sources consider that mothers receiving antineoplastic therapy should not breastfeed, especially with alkylating agents such as cisplatin. [1] Excretion of … WebSep 15, 2024 · The most common side effects of Cisplatin include: nausea, vomiting (may be severe), diarrhea, temporary hair loss, loss in ability to taste food, hiccups, dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration Tell the doctor if you have any side effect that bothers you or that does not go away.
WebAim: Cisplatin (CP) induced acute renal failure (ARF) has previously been associated with decreased urinary prostaglandin E2 (PGE2) excretion and reduced aquaporin 2 (AQP2) expression in kidney collecting duct.
WebAbstract. The purpose of this study was to determine long-term renal platinum excretion after chemotherapy with cisplatin. We examined urinary platinum concentrations in 23 … iu health maternityWebSep 6, 2024 · The parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the dose excreted within one hour after administration of 50 mg/m2. The … iu health methodist hospital gift shopWebCisplatin (90 mg/m2) was administered in a 5-minute bolus IV infusion to dogs at 8 AM (n = 6) or 4 PM (n = 6). Blood and urine samples were collected over a 4-hour period for statistical moment pharmacokinetic analysis. networker bahireWebJan 11, 2024 · Starting right after your get your chemotherapy treatment, drink at least 4 (8-ounce) glasses of liquids before 8:00 a.m. the next day. The day after your … networker baire full movie online watchWebOct 5, 2014 · The kidney accumulates cisplatin to a greater degree than other organs and is the major route for its excretion. The cisplatin concentration in proximal tubular … iu health medical recordWebDec 26, 2024 · Increased excretion of phosphate occurs primarily in the renal system. The proximal renal tubule reabsorbs up to 70% of filtered phosphate normally, and the distal tubule reabsorbs up to 15% of filtered phosphate. ... cisplatin, or pamidronate, current treatment for diabetic ketoacidosis, and any hospitalization requiring an Intensive care … iu health methodist south labWebExcretion rates for selected cytotoxic agents Cytotoxic agent Excretion rate Duration after therapy for which PPE is recommended when handling excreta* 5-Fluorouracil Urine: unchanged up to 15% over 24 Hours Urine: 2 Days Faeces: 5 Days Bleomycin Urine: … networker baire cast