WebApr 16, 2024 · The latter contains up to 40 different cardenolide glycosides of which convallatoxin is the major toxin causing cardiac arrhythmia. Convallaria majalis L. ... All parts of the plant contain the toxic cardenolide glycosides which are only formed in the above surface organs of the plant. Highest toxin concentrations are found in very young … WebMaterials and methods: Aliquots of a drug-free serum pool and a digoxin serum pool were supplemented with nanograms to 1 μg quantities of convallatoxin or 1.0 and 2.5 μL of lily of the valley extract per milliliter of serum followed by measurement of digoxin concentrations using the LOCI and ADVIA Centaur digoxin assays.
Convallatoxin inhibits IL-1β production by suppressing …
WebSep 26, 2014 · Drug rescue of P-gp processing mutants containing an arginine at each position in TM5 was used to identify positions facing the lipid or internal aqueous chamber. WebConvallatoxin is used as a cardiotonic. The dried rhizome, known as Convallaria root, has also been used as a cardiotonic and diuretic. In veterinary science, it has been used as a diuretic and cardiac stimulant. Cardiac glycosides compounds are potent inhibitors of cellular Na + /K + -ATPase. rooted coffee evans ga
The Use of Convallaria and Crataegus in the Treatment of …
Convallatoxin is a digitalis like compound (DLC), which is mainly used as a cardiac glycoside since it can inhibit the Na ,K -ATPase in congestive heart failure or arrythmias, which causes an inotropic effect, same as many other digitalis like compounds. The Na ,K -ATPase creates the ion gradient between the intra- and extracellular domains of a cell. It does this by transporting three sodium ions out of and two potassium ions into the cell. If the Na ,K -ATPase is inhibited, potassium will a… WebSep 1, 2012 · Lily of the Valley Root (Convallaria) 100-400 mg per day, containing Convallatoxin (Convallaria alkaloid) 0.4 mg bid … WebOver the years, convallatoxin has been recognized as a potential novel drug to treat malignant tumors due to its strong anti-cancer activity and chemotherapy sensitization effect . Schneider et al. [ 5 ] have reported that convallatoxin exerts potent anti-proliferative, anti-migratory, and anti-invasive effects on lung cancer cells [ 23 ]. rooted.com