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WebNov 18, 2011 · To test this hypothesis, we combined lymphocyte-restricted hCD2-Cre transgenic, Rosa26-YFP-Cre-reporter, and Dicer1 ‘floxed’ mice. In this model, 25–50% of Dicer1 wt/wt NK cells are YFP + marking expression of Cre. As expected, YFP+ NK cells from Dicer1 fl/fl and fl/wt mice were confirmed to excise Dicer1, ... WebApr 17, 2015 · Altogether, our data provide the first detailed assessment of hCD2-iCre and Vav-iCre mediated deletion of floxed genes during lymphocyte development from hematopoietic stem cells and open up … nifty fifty betfred results check
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WebMar 8, 2024 · Upon induction of Cre recombinase, the PiggyBac transposon cassette is inverted to drive its expression (“Flip”). This leads to excision of the PiggyBac cassette and its quasi-random insertion at a distal site … WebCommon Name: hCD2-iCre Mice harboring the hCD2-iCre transgene have the human CD2 promoter and locus control region (LCR) directing expression of an optimized variant of Cre recombinase (iCre) to T cells and B cells (all B cell and T cell progenitors) and mice may be useful for generating conditional mutations in T cells and B cells. WebApr 17, 2015 · Vav-iCre expresses active Cre in fetal and adult hematopoietic stem cells and all descendants, hCD2-iCre in immature and mature B and T lymphocytes. To better … nifty fifty bubble