Thiophene toxicity
http://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.5b00364#:~:text=Drug%20metabolism%20of%20thiophene%20containing%20substrates%20by%20cytochrome,thrombotic%20thrombocytopenic%20purpura%20%28clopidogrel%29%2C%20and%20aplastic%20anemia%20%28ticlopidine%29. WebJan 14, 2024 · ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg ... Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents.
Thiophene toxicity
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WebThe thiophene isostere (11) of the carcinogen 4-aminobiphenyl (12) is at least 20-fold less toxic to mice than is its benzenoid parent, and is noncarcinogenic when tested under conditions where 4-aminobiphenyl is carcinogenic 〈82UP10500〉. Web231100000252 nontoxic Toxicity 0.000 claims abstract description 30; 230000002265 prevention Effects 0.000 claims abstract description 15; ... YTPLMLYBLZKORZ-UHFFFAOYSA-N thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 3; 125000004044 trifluoroacetyl group Chemical group …
WebNov 1, 2024 · Evaluation of benzo(c)thiophene-1,3-dione acute toxicity. The benzo(c)thiophene-1,3-dione administration to mice at doses of 5000 and 1000 mg/kg caused no changes in behaviour. Moreover, no death was recorded during 16 days of the study in mice under study. On 17th day of infection mice were sacrificed by cervical … WebJul 17, 2024 · Articaine’s toxicity is comparable to that of lidocaine, 4,12 but Malamed et al. cautioned use of both lidocaine and articaine in patients with liver or cardiovascular impairment as amide ...
Webproposed intermediate may be responsible for the toxic effects of thiophene. Bray et al. (1971) found that rats given single oral doses of 200-300 mg/kg thiophene excreted 32% … WebApr 13, 2024 · The CBT-SiPc purity was confirmed by 1 H NMR, HPLC, and HRMS spectra. Resonances at 9.63 and 8.38 ppm were assigned to signals of the phthalocyanine ring with 16 protons. The three resonances at 5.61–5.63, 7.89–7.96, and 8.10–8.12 were designated to the six aromatic protons of chlorophenyl thiophene, while the four sets of resonances …
WebThe four thiophene compounds in Figure 2 have all been identified as causing some toxicity. 25 There is evidence that oxidative metabolism is associated with the toxicity, and there are various proposals 26 for the nature of the toxic intermediate(s), including:
WebThe aim of this work was to evaluate the impact of the thiophene-derived aminophosphonates 1–6 on seedling emergence and growth of monocotyledonous oat (Avena sativa) and dicotyledonous radish (Raphanus sativus L.), and phytotoxicity against three persistent and resistant weeds (Galinsoga parviflora Cav., Rumex acetosa … gregory easy peasy day xsWebDec 12, 2015 · The structure and toxicity relationship of the dibenzo-1,4-diazepine derivatives has been investigated using quantum chemical calculations at the density functional theory level/B3LYP with the 6-311G(d,p) basis sets by electron or hydrogen transfer calculations as model for the reaction prediction between the derivatives and the … gregory eaton mediatorWebThiophene, also known as thiofuran, is a cyclic compound containing four carbon atoms and one sulfur atom in the ring. Thiophene is an analog to furan and pyrrole where the sulfur atom is replaced by O and NH respectively. Thiophene is a toxic, flammable, and colorless liquid; insoluble in water (soluble in most organic solvents including ... gregory eaton karoubWebJan 1, 2011 · Thiophene is a toxic and flammable aromatic co mpound. ... (IC50 = 3.023 and 3.12 μM) were the most promising candidates on both cells with good selective toxicity-sparing normal cells. A further ... gregory eaton-chiangWebAug 18, 2014 · The question therefore arises as to which factors significantly influence the toxicity of thiophene-containing drugs. There is no easy way to answer this question. … gregory eaton attorneyWebProduct name : Thiophene Product Number : T31801 Brand : Aldrich CAS-No. : 110-02-1 1.2 Relevant identified uses of the substance or mixture and uses advised against ... Acute inhalation toxicity - Possible damages:, Irritation symptoms in the respiratory tract. Specific target organ toxicity - repeated exposure Aspiration hazard Additional ... gregory eaton organWebDec 1, 2024 · The toxicity of thiophene and its intermediate products were predicted by ECOSAR program (Table 4). According to the European Union criteria, the acute toxicity … fibervision covington ga jobs