2024 Trim37 plk4

Trim37 plk4

Author: hbum

August undefined, 2024

WebSep 9, 2024 · Fig. 1: TRIM37 levels determine mitotic outcomes and cancer-specific sensitivity to PLK4 inhibition. a, Still images from time lapse sequences showing … WebTo assess if elevated TRIM37 expression in cancers confers enhanced sensitivity to PLK4 inhibition, we analyzed two breast cancer (BT474 and MCF7) and four neuroblastoma …

TRIM37 controls cancer-specific vulnerability to PLK4

WebInterestingly, increased TRIM37 protein levels sensitize cells to the PLK4 inhibitor centrinone. In this review, we cover the emerging roles of TRIM37 in centrosome biology … WebSupplementary Data 5. List of genes linked to various male infertility disorders and plotted in Fig. 3c. The annotations are largely based on Oud et al. 2024, Hum Reprod (ref 7. main text) and only genes with high confidence protein-protein interactions (>0.7) are provided. mode norm core コットンツイルマキシハイネックコート

Evidence that CEP192 is the target of TRIM37 that

WebDepartment of Veterans Affairs Washington, DC 20420 GENERAL PROCEDURES VA Directive 7125 Transmittal Sheet November 7, 1994 1. REASON FOR ISSUE. To adhere … WebJan 25, 2024 · TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue … WebJun 27, 2024 · We found that TRIM37 is a key mediator of growth arrest after partial or full PLK4 inhibition. Interestingly, PLK4 cellular mobility decreased in a dose-dependent manner after centrinone B treatment. mode ii レビュー

Human Cep192 and Cep152 cooperate in Plk4 recruitment and …

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified ...

WebAug 5, 2024 · Serine/threonine-protein kinase polo-like kinase 4 (PLK4) is a mitosis-associated protein kinase that plays a vital role in the duplication of centrioles in dividing cells and is considered a promising target of synthetic … Weba．在 plk4 的正常调控下，中心体在每个细胞周期的间期复制一次: b．plk4 失活后，非中心体型纺锤体组装取决于 trim37 的水平: c．在 plk4 失活的情况下，trim37 基因过度表达可促使癌细胞分裂: d．在 trim37 基因过度表达的细胞中可能观察到染色体数目加倍 alice + olivia lavera strapless jumpsuitWebSep 9, 2024 · Thus, TRIM37 is an essential determinant of mitotic vulnerability to PLK4 inhibition. Linkage of TRIM37 to prevalent cancer-associated genomic changes-including … mode tokimi ソフト牛革パンプス

"WebSpecifically, inhibition of polo-like kinase 4 (PLK4) using small molecules leads to centrosome depletion, which triggers mitotic catastrophe in cells that exhibit amplicon-directed overexpression of TRIM37. To explain this effect, we identify TRIM37 as a negative regulator of centrosomal pericentriolar material. " - Trim37 plk4

Trim37 plk4

Design, synthesis, and biological evaluation of novel pyrazolo …

WebSep 9, 2024 · Extended Data Fig. 2 Inhibitor selectivity for PLK4—and not other kinases—is required for the synthetic lethal killing of cells overexpressing TRIM37. a, Representative … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆

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WebJun 27, 2024 · PLK4 activity decreases in a dose-dependent manner upon centrinone B addition. TRIM37 promotes PLK4 auto-phosphorylation (orange circles) outside the … WebApr 11, 2024 · The ubiquitin ligase TRIM37 localizes to centrosomes, but its centrosomal roles are not yet defined. ... In Xenopus extracts, PLK4 assemblies additionally recruit …

WebJul 1, 2024 · TRIM37 deletion restored the ability of cells to proliferate in centrinone. Thus, centrosome removal via Plk4 inhibition appears to be a promising strategy for therapeutic treatment of neuroblastomas and potentially other cancers with high levels of … WebTRIM37 interacts with and ubiquitinates PLK4 but does not alter PLK4 levels, suggesting that rather than promoting its degradation, TRIM37-mediated ubiquitination prevents the incorporation of PLK4 into ectopic assemblies ( Meitinger et al., 2024 ).

WebSep 17, 2024 · By contrast, elevated TRIM37 expression inhibits acentrosomal spindle assembly through a distinct mechanism that involves degradation of the centrosomal … Web豆丁网是面向全球的中文社会化阅读分享平台，拥有商业,教育,研究报告,行业资料,学术论文,认证考试,星座,心理学等数亿实用 ...

WebSep 17, 2024 · Thus, TRIM37 is an essential determinant of mitotic vulnerability to PLK4 inhibition. Linkage of TRIM37 to prevalent cancer-associated genomic changes—including 17q gain in neuroblastoma and ...

WebAug 5, 2024 · TRIM37 amplification has been observed in a large number of cancers, and synthetic lethality of PLK4 inhibitors in TRIM37-amplified breast cancer, which accounts for approximately 10% of breast cancers, has been confirmed [18, 19]. Therefore, inhibition of PLK4 using PLK4 small-molecule inhibitors provides a new approach to trigger selective ... mode neroセーフティプラス3WebJun 15, 2024 · Abstract. Amplification and copy number alterations of the 17q23 amplicon are common in breast cancer and neuroblastoma and have been associated with early relapse and poor prognosis. Recent work identified a key vulnerability associated with amplicon-driven overexpression of TRIM37 in these tumor types (Meitinger et al. 2024; … mode k's 札幌宮の森店【モードケイズ】WebThe PLKs comprise a protein family that has been identified as critical for spindle formation (26), centrosome duplication (27), and mitotic entry (28). PLK4 is the most structurally... alice + olivia size guideWeb中央日報日本語版 2013 年 4月2日 ^ Min, Sung Kil. (2009, January). Hwabyung : Culture and Dynamic Analysis. mode kaori モードカオリWebNov 2, 2024 · TRIM37 exerted bidirectional control over mitosis in PLK4-inhibited cells. Whereas TRIM37 overexpression led to catastrophic mitotic failure in cells treated with a … mode norm core コットン天竺3dスリーブプルオーバーWebTRIM37 controls cancer-specific vulnerability to PLK4 inhibition. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. TRIM37 has a role in … mode norm core スウェットジップマキシワンピースWebThus, TRIM37 is an essential determinant of mitotic vulnerability to PLK4 inhibition. Linkage of TRIM37 to prevalent cancer-associated genomic changes-including 17q gain in … alice \u0026 hatter pte ltd