Triphosphohydrolase
WebPhosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed: 23602554, PubMed: 23601106, PubMed: 29610582, PubMed: 29670289 ). WebNov 11, 2024 · The dNTP triphosphohydrolase SAMHD1 is a regulator of cellular dNTP pools. Given its central role in nucleotide metabolism, SAMHD1 performs important functions in cellular homeostasis, cell cycle regulation, and innate immunity. It therefore represents a high-profile target for small molecule drug design.
Triphosphohydrolase
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WebOct 31, 2024 · The dNTP triphosphohydrolase SAMHD1 is a regulator of cellular dNTP pools. Given its central role in nucleotide metabolism, SAMHD1 performs important … WebNov 12, 2013 · SAMHD1 possesses deoxynucleoside triphosphate triphosphohydrolase (dNTPase) activity 24,25.
WebOct 31, 2024 · The dNTP triphosphohydrolase SAMHD1 is a regulator of cellular dNTP pools. Given its central role in nucleotide metabolism, SAMHD1 performs important functions in cellular homeostasis, cell cycle regulation, and innate immunity. It therefore represents a high-profile target for small molecule drug design. WebMar 9, 2015 · Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a recently discovered enzyme that plays a central role in nucleotide metabolism and innate immunity. SAMHD1 has deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase activity that depletes the dNTP substrates required for DNA …
WebDec 1, 2024 · We investigate the role of protein oxidation in regulation of SAMHD1 catalysis. Results: Here we report that SAMHD1 is a major target for redox regulation of nucleotide … WebDec 6, 2015 · My work characterized the HIV restriction factor, SamHD1, as a deoxynucleoside triphosphohydrolase. I further worked to explore the role of SamHD1 disease mutants in associated with Aicardi-Goutieres Syndrome. I was responsible for the synthetic generation of mutant proteins, their expression, purification, and enzymatic …
WebMay 25, 2006 · Deoxyribonucleoside triphosphate triphosphohydrolase from Thermus thermophilus (Tt-dNTPase) has a unique regulatory mechanism for the degradation of deoxyribonucleoside triphosphates (dNTPs). Whereas the Escherichia coli homologue specifically hydrolyzes dGTP alone, dNTPs act as both substrate and activator for Tt …
WebSep 10, 2024 · Summary Deoxyguanosinetriphosphate triphosphohydrolase (dGTPase) is a unique nucleoside triphosphatase in that it hydrolyzes dGTP to deoxyguanosine and … cabins near portsmouth ohioWebDive into the research topics of 'The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch'. Together they form a unique fingerprint. Oxidation-Reduction Medicine & Life Sciences 100%. Proliferative Chemical Compounds 69%. Catalysis Medicine & Life Sciences 62%. triphosphoric ... cabins near pisgah national forestWebNov 6, 2011 · Here we show that human SAMHD1 is a potent dGTP-stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent … cabins near reelfoot lake tnWebJan 22, 2024 · dNTP triphosphohydrolase Crystal structure 1. Introduction The fidelity of DNA replication relies on a balanced dNTP pool within the cell [ 1, 2]. Imbalanced ratios of the four canonical dNTPs or of dNTPs to NTPs have been shown to … cabins near rangeley maineWebNov 27, 2024 · The dNTP triphosphohydrolase SAMHD1 is a regulator of cellular dNTP pools. Given its central role in nucleotide metabolism, SAMHD1 performs important … cabins near ricketts glen for saleWebJan 22, 2024 · dNTP triphosphohydrolase (TPH) belongs to the histidine/aspartate (HD) superfamily and catalyzes the hydrolysis of dNTPs into 2′-deoxyribonucleoside and inorganic triphosphate. TPHs are required for cellular dNTP homeostasis and DNA replication fidelity and are employed as a host defense mechanism. club med skiing val thorensWebDec 23, 2011 · The nucleotide phosphohydrolase reactions contained 20 m m Tris-HCl (pH 7.5), 2 m m dithiothreitol, 1 μ m EDTA, 5 m m MgCl 2, the indicated nucleotides, and SAMHD1 enzyme. Reactions were incubated for the indicated times at 25 °C and stopped by the addition of EDTA to 5 m m final concentration. cabins near rehoboth beach