Ultrafine anaphase bridges
Webstructure-specific nuclease; ultrafine anaphase bridge; chromosome segregation; mitotic DNA synthesis; genome stability 1. Introduction DNA replication requires the unwinding of the parental DNA duplex by the replicative helicase, which leads to the formation of branched DNA structures that are known as replication forks (RFs). http://sro.sussex.ac.uk/id/eprint/82640/1/genes-10-00232.pdf
Ultrafine anaphase bridges
Did you know?
Web12 Mar 2015 · Here, the authors report that topoisomerase IIβ binding protein 1 recruits topoisomerase IIα to centromere-associated ultra-fine anaphase bridges to enable their … WebIntriguingly replication fork stalling and DNA breakage correlate with the appearance of structures that are analogous to ultrafine anaphase bridges (UFBs), which frequently form …
Webstructure-specific nuclease; ultrafine anaphase bridge; chromosome segregation; mitotic DNA synthesis; genome stability 1. Introduction DNA replication requires the unwinding of … WebPreviously, anaphase bridges were presumed to be a rare occurrence, however, recent evidence has shown that in most mitosis ultrafine anaphase bridges (UFBs) are …
Web17 Nov 2024 · The fate of unresolved recombination intermediates arising in cells lacking two nucleases required for resolution are determined and it is found that intermediates … Web18 Dec 2024 · We find that intermediates persist until mitosis and form a distinct class of anaphase bridges, which we term homologous recombination ultra-fine bridges (HR-UFBs).
Web22 Aug 2013 · The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase bridges (UFBs) in mitosis alongside a complex of DNA repair proteins, including the Bloom’s syndrome protein (BLM). However, very little is known about the function of PICH or how it is recruited to UFBs. Using a combination of microfluidics, fluorescence …
WebEventually, in mitosis, they can evolve into ultrafine anaphase bridges (UFBs) connecting sister chromatids, which can finally lead to chromosomal instability. In the following sections, we focus on CFSs as an example of the extraordinary processes that cells carry out in mitosis to resolve problems that originated during the previous S-phase, in order to … row.getcell 3Web26 Apr 2012 · Centromeric ultrafine anaphase bridges are physiological DNA structures thought to contain unresolved DNA catenations between the centromeres separating during anaphase. BLM and PICH helicases colocalize at these ultrafine anaphase bridges and promote their resolution. row german excelWeb30 Aug 2024 · Failure to process joint DNA molecules in mitosis leads to persistent entangling of sister chromatids, generating ultrafine DNA bridges (UFBs) as cells … stream scooby doo ghoul schoolWebChromatin bridge is a mitotic occurrence that forms when telomeres of sister chromatids fuse together and fail to completely segregate into their respective daughter cells. … streams cppWebFailure to properly disentangle catenated sister chromatids can lead to the formation of bulky or ultrafine anaphase bridges, and ultimately genome instability. In this review we present an overview of the current state of knowledge of how sister chromatid decatenation is carried out, with particular focus on the role of TOP2A and TOPBP1 in this process. stream screenshotWeb14 Feb 2024 · It has been proposed by McClintock that anaphase bridges drive chromosomal rearrangements through a so-called breakage-fusion-bridge (BFB) cycle, where multiple rounds of the joined chromatid ... streams college footballWebA new class of ultrafine anaphase bridges generated by homologous recombination Ying Wai Chan and Stephen C. West Department of DNA Recombination and Repair, The … streamscreen mac os x